TRILOGY

Eligibility

Persons may be eligible to participate in this trial if they meet the following criteria.

• Have has a US/NSTEMI index event within 10 days prior to randomization
• Had a medical management strategy decision made with reasonable certainty that neither PCI or CABG is planned for treatment of the index event
• Had at least 1 of 4 specified high-risk features at the time of the UA/NSTEMI event

Persons may be excluded from this trial if they meet the following criteria.

• Decision for medical management greater than 72 hours after onset of index event without commercial clopidogrel treatment within 72 hours following onset of the index event
• Insignificant CAD on coronary angiography if performed for Index Event (absence of greter thn or equal to 30% stenosis in at least one native vessel)
• Previous or planned PCI or CABG for the index event
• PCI/CABG within previous 30 days
• STEMI as the index event
• Cardiogenic shock, Refractory ventricular arrhythmias, NYHA class IV CHF within previous 24 hours
• History of ischemic or hemorrhagic stroke, TIA, Intracranial neoplasm, arteiovenous malformation, or aneurysm
• History of spontaneous GI or non-GI bleeding requiring hospitalization for treatment, unless definitive Rx has occurred and there is low likelihood of recurrence
• Hemodialysis or peritoneal dialysis